Posts Tagged ‘Proscar’
About Propecia
Propecia is used for the treatment of male pattern hair loss (androgenetic alopecia) in men with established efficacy in ages between 18 to 41 years. But, hair re-growth is possible only in men with mild to moderate hair loss of the vertex and anterior mid-scalp area. However, the efficacy of Propecia has not been established in men with bitemporal recession.
Finasteride, the main ingredient in Propecia, blocks the conversion of testosterone into DHT, thereby stopping hair loss and aiding in hair re-growth. Finasteride comes in tablet form and is available in strength of 1mg only for hair loss treatment. In addition, numerous side effects have been reported with this drug, including impotence, decreased libido, and breast enlargement.
Brand-name finasteride (Proscar or Propecia) is manufactured by Merck and Co., Inc.
About Male Pattern Baldness
Male pattern baldness is a universal condition found in men who experience thinning of the hair on the scalp which starts with a gradual decline in men in their 20s. Oftentimes, this thinning of hair results in a receding hairline and/or balding on the top of the head.
It is generally believed by the doctors that male pattern baldness is by and large due to heredity and in addition, depends on hormonal effects also. This type of hair loss is generally referred to as androgenetic alopecia.
Hair is made up of hair follicles which are tiny pouch like bags found just under the surface of the skin. A single hair will stay in the follicle for about 3 years which is then shed and a new hair grows from the same follicle. This cycle of growth, shedding and new growth goes on throughout one’s life. The following pattern thought to occur in men as they gradually become bald which includes:
• Affected hair follicles on the scalp gradually become smaller than normal
• As the follicle shrinks, each new hair is thinner than the previous one
• Before falling out, each new hair grows for much less time than the normal 3 years or so
• Eventually, all that remains is a much smaller hair follicle and a thin stump of hair that does not grow out to the skin surface
Male hormones are responsible for these changes. Hair follicles convert testosterone, the male hormone, into another hormone called dihydrotestosterone. For reasons not yet unveiled, affected hair follicles become more sensitive to dihydrotestosterone, which causes the hair follicles to shrink. However, it is known that different hair follicles are affected at different times which make the balding process gradual.
Moreover, it is also not clear why only scalp hair is affected, and not the hair in the other areas like the beard or the armpits in men. But, male pattern baldness occurs gradually over time. Similarly, Propecia also has a gradual effect on hair re-growth.
Propecia for Men Hair Loss treatment
For most men, Propecia aids in increasing the number of scalp hair in the first year of treatment itself. Propecia helps to fill in the thin or balding areas of the scalp. In addition, hair loss slows down. Although, the results may vary, generally it is not possible to re-grow all of the lost hair. However, there is no proof as to Propecia working in the treatment of receding hairline in the temporal area on both sides of the head.
Propecia must be taken daily for three months or more before any benefit can be seen. Known to work over the long term, Propecia is an ongoing treatment for hair re-growth. However, if Propecia has not worked for you in twelve months, further treatment is not likely to bring any benefit. In addition, if Propecia intake is stopped, there will be a likely loss in the hair that was gained within 12 months of stopping treatment.
How does Propecia work?
Finasteride, the main ingredient in Propecia, is a competitive and specific inhibitor of Type II 5a-reductase, an intracellular enzyme that converts the androgen testosterone into DHT. Two distinct isozymes found in humans, Type I and II, are differentially expressed in tissues at different developmental stages. In humans, Type I 5a-reductase is predominant in the sebaceous glands including the scalp and liver and is responsible for approximately one-third of circulating DHT. Meanwhile, Type II 5a-reductase isozyme is primarily found in the prostate, seminal vesicles, epididymides, hair follicles and the liver and is responsible for two-thirds of the circulating DHT.
In humans, finateride’s mechanism of action is primarily based on its preferential inhibition of the Type II isozyme. For both isozymes, finasteride inhibits and reduces the inhibitor to dihydrofinasteride. The turnover for the enzyme complex is slow and therefore the hair re-growth is slow.
Finasteride has no similarity with the androgen receptor and has no androgenic, antiandrogenic, estrogenic, antiestrogenic, or progestational effects. Propecia produces a rapid reduction in serum DHT concentration and has the ability to reach about 65% suppression within 24 hours of taking the 1mg oral dose.
In men with androgenetic alopecia, the balding scalp contains miniaturized hair follicles and increased amounts of DHT as compared to a hairy scalp. Use of Propecia successfully reduces scalp and serum DHT concentrations in these men. By this mechanism, finasteride interrupts a key factor in the progress of androgenetic alopecia in those patients who are genetically predisposed.
Who should buy Propecia?
Propecia has been introduced for the treatment of male pattern hair loss in men and should not be taken by women or children. Propecia can be taken by:
• Men only above the age of 18 years
• Anyone who is not allergic to any of the ingredients of Propecia
Women who are or may potentially be pregnant should not use Propecia or handle crushed or broken Propecia tablets. Because, if a pregnant woman with a male baby absorbs the active ingredient in Propecia, either by swallowing or through the skin, it may cause abnormalities to foetus’ genital organs.
Propecia dosages
Propecia 1mg tablet is meant for oral administration and is the recommended daily dosage. These tablets are film-coated and contain 1mg of finasteride. it may be administered with or without meals.
In general, three months of regular use of Propecia is required before any benefit can be observed. Continuous use is recommended to sustain gained benefits. Withdrawal of treatment will lead to reversal of effect within 12 months.
Coated Propecia tablets help prevent contact with the active ingredient finasteride during normal handling, provided that the tablets are not broken or crushed.
Propecia (finasteride) is a synthetic 4-azasteroid compound and a specific inhibitor of steroid Type II 5a-reductase which is an intracellular enzyme that converts androgen testosterone into 5a-dihydrotestosterone (DHT).
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The most commonly prescribed treatments for hereditary pattern baldness by dermatologists and hair-loss clinics around the world are Propecia, or some other form of finasteride, such as Proscar, and Rogaine, or its generic form – minoxidil. Some doctors will also recommend you to use supplementary vitamin and mineral pills, some special anti-dandruff shampoos, such as Nizoral, and a laser comb. But very few dermatologists and hair-loss clinics will recommend their patients to buy natural hair-loss remedies. But there are so many of them out there and most of them claim that they work better than Propecia or any other medicinal treatment prescribed by your doctor, while being free of potential negative side-effects so typical of prescription medicine. And some of the manufacturers seem to be so convinced about the effectiveness of their product as to offer you a full money-back guarantee. Or is it a catch?
First, one needs to differentiate between medical practice and the pharmaceutical industry on one hand and the cosmetics industry on the other. The medicinal and pharmaceuticals fields are strictly regulated in almost every country in the world, ensuring patient’s safety. Doctors can only prescribe certain medications for given conditions and the safety and efficacy of such medications has to be approved by the national health supervisory authority. Such products are considered safe and clinically proven to help treat the given condition. If your doctor recommends you some other, unproven natural hair-loss remedy, they will be taking the risk of supporting a treatment that has not been subjected to any rigorous clinical testing. Most doctors would not do that since they have no guarantee that such a product would be beneficial to their patients and recommending a bad product could hurt their reputation.
Although some of the active ingredients in natural hair-loss remedies may pose a health risk, despite the common belief that they are safe, this is not their only controversy. The principal question is whether the natural hair-loss remedies are effective in treating baldness. They might be effective to a certain degree since many of them contain generic minoxidil, the only existing, clinically-proven and FDA-approved, topical medicine for treating hereditary hair loss. Additional components usually include minerals, vitamins, essential fatty acids, amino acids and herbal extracts. Most of these substances are either essential to ensuring healthy growth of hair and skin or they have been shown to promote hair growth, mostly in small studies conducted on rodents. They have never been clinically tested for treating hair loss and thus their effectiveness and mechanism of action are unknown. They may or may not help promote new hair growth but since little clinical proof of their efficacy exists, the only way to find out is to buy them and try for yourself. And should they fail to work as promised, you may find out that the generous money-back guarantee, after deducting their incurred costs, only applies to a small percentage of the original price. This is the way some natural hair-loss product manufacturers make their money.
In summary, no natural hair-loss remedy has ever been clinically proven and independently verified to treat hereditary pattern baldness. This does not necessarily mean that all natural hair-loss remedies are ineffective as they might work for some of us. However, they are usually overrated and should at best be expected to maintain your existing hair rather than grow new hair from a bald spot.
The most commonly prescribed treatments for hereditary pattern baldness are Propecia and Rogaine. Some doctors will also recommend you to use supplementary vitamin and mineral pills, some special anti-dandruff shampoos and a laser comb. But very few dermatologists and hair-loss clinics would recommend their patients to buy natural hair-loss remedies.
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Hair Loss Articles: http://www.article-buzz.com